21c Museum Hotel Louisville is the original expression of the 21c concept, set on historic West Main Street along Museum Row. The property combines a contemporary art museum, a boutique hotel and Proof on Main, its established restaurant, within a collection of rehabilitated warehouse buildings. Guest rooms balance clean modern design with the scale and character of the historic architecture, while galleries and installations appear throughout the public spaces. Its location places the hotel close to Louisville’s bourbon, arts and downtown dining scene, giving the stay a strong connection to the city’s creative identity.